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Expression of a lysosomal-targeted NNT homolog would likely increase the cytoplasmic [NAD + ]/[NADH] more effectively than increasing the cytoplasmic [NADPH]/[NADP + ] due to the limiting 0.1 M cytoplasmic [NADH] that is approximately 1080-fold lower than the cytoplasmic [NADP + ]

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This is the rationale behind topical and oral use for eczema, psoriasis, and dermatitis, though dedicated human trials for those conditions are not there yet

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Regulatory T (Treg) cells typically confer genetic resistance against organ-specific autoimmunity by actively suppressing the effector functions of self-antigen-reactive T cells, thereby inducing peripheral tolerance